A photomicrograph showing promyelocytic leukaemia. Acute promyelocytic leukemia (APL) is a subtype of the cancer acute myeloid leukemia (AML). APL is characterised by abnormal, heavily granulated promyelocytes, a form of white blood cells. APL results in the accumulation of these atypical promyelocytes in the bone marrow and peripheral blood, which replace normal blood cells. APL represents about one percent of childhood leukaemia. APL is found more often in children between the ages of two and three, and in adults over 40. However, it has also been found in older children and teenagers. APL is found more frequently in children of hispanic and mediterranean origins.
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