A photomicrograph of Chronic lymphocytic leukaemia (CLL), a defect in the body's ability to produce normal white blood cells. These blood cells are produced primarily in the bone marrow. It was discovered that by selectively "destroying" the bone marrow with high doses of chemotherapy and total body irradiation (TBI) and then replacing that destroyed marrow with healthy marrow from a donor, the effects of leukemia could be stopped - and sometimes reversed completely. Transplants where healthy marrow is recieved from a donor are called allogenic transplants.
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